BDBM92625 Dimethoxyquinoline, 2

SMILES COc1cc2c(ccnc2cc1OC)Oc3ccc(nc3)NC(=O)C4=CC=CN(C4=O)Cc5ccccc5

InChI Key InChIKey=MIRAJAFOEINWJO-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 92625   

TargetTyrosine-protein kinase SYK(Human)
Pfizer

LigandPNGBDBM92625(Dimethoxyquinoline, 2)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:A Lance TR-FRET assay (Perkin Elmer) was used to measure and compare the potency of compounds against Syk kinase domain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Pfizer

LigandPNGBDBM92625(Dimethoxyquinoline, 2)
Affinity DataIC50: 100nMAssay Description:Inhibition of Syk (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Pfizer

LigandPNGBDBM92625(Dimethoxyquinoline, 2)
Affinity DataIC50: 100nMAssay Description:Inhibition of SYK (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 25 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)