BDBM92605 DHOD Inhibitor, 4::US8703811, 5

SMILES O=C(NC1CC1)c1ccc(s1)N1CCSc2ccccc12

InChI Key InChIKey=RNLKPTOJCXLFDG-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 92605   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
Harvard Medical School

LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 250nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei (strain Anka))
Harvard Medical School

LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 380nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium vivax)
Harvard Medical School

LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 280nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 7.90E+3nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
Harvard Medical School

LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 250nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei (strain Anka))
Harvard Medical School

LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 380nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium vivax)
Harvard Medical School

LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 280nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (fumarate)(Baker's yeast)
Genzyme

US Patent
LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

LigandPNGBDBM92605(US8703811, 5 | DHOD Inhibitor, 4)
Affinity DataIC50: 7.90E+3nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent