BDBM92472 Sulfonamide, 3

SMILES COc1cc(c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N(c2ccccc2)c3ccc(cc3)N)OC

InChI Key InChIKey=LOWPPNMRMWEKTJ-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 92472   

TargetBifunctional protein GlmU(Escherichia coli (strain K12))
Astrazeneca

LigandPNGBDBM92472(Sulfonamide, 3)
Affinity DataIC50: 18nMpH: 7.35Assay Description:Inhibition assay using GlmU bifuncation enzyme with various bacterial strains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional protein GlmU(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Astrazeneca

LigandPNGBDBM92472(Sulfonamide, 3)
Affinity DataIC50: 400nMpH: 7.35Assay Description:Inhibition assay using GlmU bifuncation enzyme with various bacterial strains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetBifunctional protein GlmU(Streptococcus pneumoniae)
Astrazeneca

LigandPNGBDBM92472(Sulfonamide, 3)
Affinity DataIC50: 4.00E+4nMpH: 7.35Assay Description:Inhibition assay using GlmU bifuncation enzyme with various bacterial strains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetBifunctional protein GlmU(Staphylococcus aureus (Firmicutes))
Astrazeneca

LigandPNGBDBM92472(Sulfonamide, 3)
Affinity DataIC50: 2.00E+5nMpH: 7.35Assay Description:Inhibition assay using GlmU bifuncation enzyme with various bacterial strains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetBifunctional protein GlmU(Escherichia coli (strain K12))
Astrazeneca

LigandPNGBDBM92472(Sulfonamide, 3)
Affinity DataIC50: 20nMAssay Description:Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional protein GlmU(Escherichia coli (strain K12))
Astrazeneca

LigandPNGBDBM92472(Sulfonamide, 3)
Affinity DataIC50: 20nMAssay Description:Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)