BDBM92469 2-Thioxanthine, TX4

SMILES O=c1[nH]c(=S)n(C[C@H]2CCCO2)c2nc[nH]c12

InChI Key InChIKey=RSPDBEVKURKEII-UHFFFAOYSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 92469   

TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2012
Entry Details Article
PubMed
TargetMyeloperoxidase(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 3.25E+4nMAssay Description:Inhibition of PMA-induced MPO in mouse Neutrophil incubated for 3 mins by luminometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 279nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 279nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataKd:  6.31E+4nMAssay Description:Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed