BDBM92443 MMP Inhibitor, 3::Thiophene derivative, compound 36::US8691753, 97

SMILES NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CCc1ccc(cc1)-c1cc(cs1)-c1ccccc1

InChI Key InChIKey=MMIHYNVQXYWTFM-UHFFFAOYSA-N

Data  32 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 92443   

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  1.90nM ΔG°:  -11.9kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  1.92nM ΔG°:  -11.9kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  3.70nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetNeutrophil collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  410nM ΔG°:  -8.71kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  410nM ΔG°:  -8.71kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  684nM ΔG°:  -8.40kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  684nM ΔG°:  -8.40kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetStromelysin-2(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  693nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetNeutrophil collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  694nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  714nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetStromelysin-2(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  872nM ΔG°:  -8.26kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetStromelysin-2(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  872nM ΔG°:  -8.26kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14 [1-20,P8S](Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+3nM ΔG°: >-8.18kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+3nM ΔG°: >-8.18kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+3nM ΔG°: >-8.18kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetMatrilysin(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+3nM ΔG°: >-8.18kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  1.06E+3nM ΔG°:  -8.15kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  2.01E+3nM ΔG°:  -7.77kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  3.01E+3nM ΔG°:  -7.53kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi:  3.88E+3nM ΔG°:  -7.38kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetStromelysin-1(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetMatrilysin(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent

TargetAngiotensin-converting enzyme(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(US8691753, 97 | Thiophene derivative, compound 36 ...)
Affinity DataKi: >1.00E+5nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
Go to US Patent