BDBM9072 2-[8-(Acridin-9-ylamino)-octyl]-isoindole-1,3-dione::2-[8-(acridin-9-ylamino)octyl]-2,3-dihydro-1H-isoindole-1,3-dione::Donepezil-tacrine hybrid 21

SMILES O=C1N(CCCCCCCCNc2c3ccccc3nc3ccccc23)C(=O)c2ccccc12

InChI Key InChIKey=YDMMKANYGRAJPZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9072   

TargetAcetylcholinesterase(Bovine)
Neuropharma

LigandPNGBDBM9072(2-[8-(acridin-9-ylamino)octyl]-2,3-dihydro-1H-isoi...)
Affinity DataIC50: 1.14E+3nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Neuropharma

LigandPNGBDBM9072(2-[8-(acridin-9-ylamino)octyl]-2,3-dihydro-1H-isoi...)
Affinity DataIC50: 1.01E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed