BDBM9067 Donepezil-tacrine hybrid 12::N-[4-({2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethyl}(methyl)amino)butyl]-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetamide::N-{4-[{2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethyl}(methyl)amino]butyl}-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide

SMILES CN(CCCCNC(=O)CN1C(=O)c2ccccc2C1=O)CCNc1c2CCCCc2nc2cc(Cl)ccc12

InChI Key InChIKey=YGULXWMNDJFAQR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9067   

TargetAcetylcholinesterase(Bovine)
Neuropharma

LigandPNGBDBM9067(N-{4-[{2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 2.80nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Neuropharma

LigandPNGBDBM9067(N-{4-[{2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 75nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed