BDBM9057 Homodimeric Tacrine Analog 3k::N,N-Bis-(1,2,3,4-tetrahydro-cyclohexa[1,2,-b]pyrido-[2,3-b]pyrid-9-yl)-1,7-di-aminoheptane::N-(7-{6H,7H,8H,9H-cyclohexa[b]1,8-naphthyridin-5-ylamino}heptyl)-6H,7H,8H,9H-cyclohexa[b]1,8-naphthyridin-5-amine

SMILES C(CCCNc1c2CCCCc2nc2ncccc12)CCCNc1c2CCCCc2nc2ncccc12

InChI Key InChIKey=CFMNRJWKHXEFOQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 9057   

TargetAcetylcholinesterase(Rat)
National Defense Medical Center

LigandPNGBDBM9057(N,N-Bis-(1,2,3,4-tetrahydro-cyclohexa[1,2,-b]pyrid...)
Affinity DataIC50: 1.30nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
National Defense Medical Center

LigandPNGBDBM9057(N,N-Bis-(1,2,3,4-tetrahydro-cyclohexa[1,2,-b]pyrid...)
Affinity DataIC50: 59nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM9057(N,N-Bis-(1,2,3,4-tetrahydro-cyclohexa[1,2,-b]pyrid...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed