BDBM9047 Bis-THA inhibitor 5::CHEMBL73800::Hexylene-Linked Bis-tacrine::Homodimeric Tacrine Analog 3a::N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]-1,2,3,4-tetrahydroacridin-9-amine

SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCNc1c2CCCCc2nc2ccccc12

InChI Key InChIKey=IYNUCVAQGDCTFO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 9047   

TargetAcetylcholinesterase(Rat)
National Defense Medical Center

LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
National Defense Medical Center

LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 83nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
National Defense Medical Center

LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 3.80nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 119nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 119nMAssay Description:Inhibition of rat serum BuChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
National Defense Medical Center

LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of rat brain AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
National Defense Medical Center

LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed