BDBM9010 6-(8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(1H-indol-3-yl)-ethyl]-amide::6-[(8-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(1H-indol-3-yl)ethyl]hexanamide::Tacrine-Melatonin Hybrid 5a

SMILES Clc1cccc2nc3CCCCc3c(NCCCCCC(=O)NCCc3c[nH]c4ccccc34)c12

InChI Key InChIKey=SZRNKXYBFFECAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 9010   

TargetAcetylcholinesterase(Bovine)
Instituto De Quimica Medica (Csic)

LigandPNGBDBM9010(6-[(8-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]...)
Affinity DataIC50: 65nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Instituto De Quimica Medica (Csic)

LigandPNGBDBM9010(6-[(8-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]...)
Affinity DataIC50: 15nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Instituto De Quimica Medica (Csic)

LigandPNGBDBM9010(6-[(8-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]...)
Affinity DataIC50: 0.870nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Instituto De Quimica Medica (Csic)

LigandPNGBDBM9010(6-[(8-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]...)
Affinity DataIC50: 23nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed