BDBM8985 6-methyl-1,2,3,4-tetrahydroacridin-9-amine::Tacrine Analogue 2

SMILES Cc1ccc2c(N)c3CCCCc3nc2c1

InChI Key InChIKey=XEAIOWJVFCHDRX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 8985   

TargetAcetylcholinesterase(Human)
University of Bologna

LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 100nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 100nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against human erythrocyte acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human recombinant AChE assessed as reduction in cholinesterase activity using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human plasmatic BuChE assessed as reduction in cholinesterase activity by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rat)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 7.83E+3nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 9.86E+4nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rat)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM8985(6-methyl-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 4.18E+4nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed