BDBM8979 CHEMBL486901::N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(1,2,3,4-tetrahydroacridin-9-ylamino)acetamide::tacrine-E2020 analog 3

SMILES O=C(CNc1c2CCCCc2nc2ccccc12)NCCC1CCN(Cc2ccccc2)CC1

InChI Key InChIKey=AYESZVAJFBYQHK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 8979   

TargetAcetylcholinesterase(Rat)
Shanghai Institute of Materia Medica

LigandPNGBDBM8979(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50: 6nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Shanghai Institute of Materia Medica

LigandPNGBDBM8979(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50: 76nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Shanghai Institute of Materia Medica

LigandPNGBDBM8979(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat cortex AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Shanghai Institute of Materia Medica

LigandPNGBDBM8979(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50: 76nMAssay Description:Inhibition of rat serum BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Shanghai Institute of Materia Medica

LigandPNGBDBM8979(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Shanghai Institute of Materia Medica

LigandPNGBDBM8979(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50: 76nMAssay Description:Inhibition of rat serum butyrylcholinesterase by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed