BDBM8971 CHEMBL129108::N-[8-(1,2,3,4-tetrahydroacridin-9-ylsulfanyl)octyl]-1,2,3,4-tetrahydroacridin-9-amine::Tacrine Dimer 4g

SMILES c1ccc2c(c1)c(c3c(n2)CCCC3)NCCCCCCCCSc4c5ccccc5nc6c4CCCC6

InChI Key InChIKey=COEYCPFFRLYNSC-UHFFFAOYSA-N

Data  10 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 8971   

TargetCarboxylic ester hydrolase(Horse)
Universita Di Siena

LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of Equine ButyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  1.65nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  1.65nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human butyrylcholine esteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  27.9nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  27.9nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  28nMAssay Description:Inhibition of human acetylcholine esteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  250nM ΔG°:  -9.00kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  250nMAssay Description:Inhibition of fetal Bovine serum AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed