BDBM8962 Bis-THA inhibitor 4::CHEMBL179732::N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]-1,2,3,4-tetrahydroacridin-9-amine::Tacrine Dimer 3a

SMILES c1ccc2c(c1)c(c3c(n2)CCCC3)NCCCCCNc4c5ccccc5nc6c4CCCC6

InChI Key InChIKey=NECDJQNRWSICKG-UHFFFAOYSA-N

Data  2 KI  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 8962   

TargetAcetylcholinesterase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM8962(CHEMBL179732 | N-[5-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM8962(CHEMBL179732 | N-[5-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataIC50: 329nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM8962(CHEMBL179732 | N-[5-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataIC50: 28nMAssay Description:Inhibition of rat brain AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM8962(CHEMBL179732 | N-[5-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataIC50: 329nMAssay Description:Inhibition of rat serum BuChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM8962(CHEMBL179732 | N-[5-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataIC50: 28nMAssay Description:Inhibition of rat AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM8962(CHEMBL179732 | N-[5-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataIC50: 329nMAssay Description:Inhibition of rat BuChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Universita Di Siena

LigandPNGBDBM8962(CHEMBL179732 | N-[5-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  100nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universita Di Siena

LigandPNGBDBM8962(CHEMBL179732 | N-[5-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  210nM ΔG°:  -9.10kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed