BDBM8891 3-(6-Methoxy-3,4-dihydronaphthalen-2-yl)pyridine::CHEMBL206351::Dihydronaphthalene 4::US9271963, 35

SMILES COc1ccc2C=C(CCc2c1)c1cccnc1

InChI Key InChIKey=WUTGTMFGCHNUET-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 8891   

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 578nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University

LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 814nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Saarland University

LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 213nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 2nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAromatase(Human)
Saarland University

LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 814nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 578nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataKi:  1.30nM IC50: 2nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2006
Entry Details Article
PubMed