BDBM8741 4-{[4-(thiophen-3-yl)-1H-imidazol-1-yl]methyl}aniline::Disubstituted imidazole 20

SMILES Nc1ccc(Cn2cnc(c2)-c2ccsc2)cc1

InChI Key InChIKey=LHODHAYQPAPVED-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 8741   

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8741(4-{[4-(thiophen-3-yl)-1H-imidazol-1-yl]methyl}anil...)
Affinity DataIC50: 2.03E+3nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli (strain K12))
Glaxosmithkline

LigandPNGBDBM8741(4-{[4-(thiophen-3-yl)-1H-imidazol-1-yl]methyl}anil...)
Affinity DataIC50: 5.14E+3nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed