BDBM8735 (2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide::(E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide::indole naphthyridinone 31

SMILES Cc1c(c2ccccc2n1C)CN(C)C(=O)/C=C/c3cc4c(nc3)NC(=O)CC4

InChI Key InChIKey=PVNPCRMKZHRPEV-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 8735   

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 60nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli (strain K12))
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 30nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 25nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetTrans-2-enoyl-ACP reductase II(Streptococcus pneumoniae)
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 3.00E+4nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 390nMAssay Description:Inhibition of Haemophilus influenzae ATCC 51907 FabI assessed as by measuring NADH consumption rateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed