BDBM86805 CAS_45263788::NSC_45263788::US9150581, RTI-7527-98::rac-2-(5-(3-chlorophenyl)-6-fluoropyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane hydrochloride

SMILES Fc1ncc(cc1-c1cccc(Cl)c1)C1CC2CCC1N2

InChI Key InChIKey=HDPYKJMZSJWSDN-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 86805   

TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86805(CAS_45263788 | NSC_45263788 | rac-2-(5-(3-chloroph...)
Affinity DataKi:  0.0730nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2012
Entry Details Article
PubMed
LigandPNGBDBM86805(CAS_45263788 | NSC_45263788 | rac-2-(5-(3-chloroph...)
Affinity DataKi:  0.0730nMAssay Description:The Ki values for the inhibition of [3H]epibatidine binding at the α4β2 nAChR in male rat cerebral cortex for compounds are listed in Table...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM86805(CAS_45263788 | NSC_45263788 | rac-2-(5-(3-chloroph...)
Affinity DataKi: >2.00E+3nMAssay Description:Compounds (10 mM) were also evaluated for inhibition of binding to a7 nAChR using [125I]iodoMLA as previously reported in Carroll et al. The binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent