BDBM86645 BC11-38-3::US9173884, BC11-38-3

SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccc(C)cc1

InChI Key InChIKey=KGBOKJHTYLICFD-UHFFFAOYSA-N

Data  23 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 86645   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 7.50E+3nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human recombinant PDE11More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
4/19/2024
Entry Details
Copy Entry DOIPubMed
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
Copy Entry DOIGo to US Patent

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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 2.13E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
Copy Entry DOIGo to US Patent

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TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
Copy Entry DOIGo to US Patent

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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
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TargetIsoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
Copy Entry DOIGo to US Patent

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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
Copy Entry DOIGo to US Patent

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TargetIsoform PDE2A2 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
Copy Entry DOIGo to US Patent

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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
8/2/2016
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 7.50E+3nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 2.13E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Boston College

US Patent

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetcAMP specific phosphodiesterase variant PDE4A-10(Human)
Boston College

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Boston College

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rat)
Boston College

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Boston College

LigandBDBM86645(BC11-38-3 | US9173884, BC11-38-3)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/5/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL