BDBM86002 (E)-1-phenyl-3-(2-hydroxyphenyl)-2-propen-1-one (8)::Chalcone, 1

SMILES Oc1ccccc1\C=C\C(=O)c1ccccc1

InChI Key InChIKey=UDOOPSJCRMKSGL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 86002   

TargetCarboxylic ester hydrolase(Horse)
Quaid-I-Azam University

LigandPNGBDBM86002(Chalcone, 1 | (E)-1-phenyl-3-(2-hydroxyphenyl)-2-p...)
Affinity DataIC50: 1.60E+4nMpH: 8.0 T: 2°CAssay Description:In vitro cholinesterase inhibition assay using electric-eel acetylcholinesterase, horse-serum butyrylcholinesterse. The IC50 values were calculated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

LigandPNGBDBM86002(Chalcone, 1 | (E)-1-phenyl-3-(2-hydroxyphenyl)-2-p...)
Affinity DataIC50: 6.00E+4nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2017
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM86002(Chalcone, 1 | (E)-1-phenyl-3-(2-hydroxyphenyl)-2-p...)
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of BChE (unknown origin) using BCh iodide as substrate preincubated for 15 mins prior to substrate addition measured after 10 mins by Ellm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Bovine)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM86002(Chalcone, 1 | (E)-1-phenyl-3-(2-hydroxyphenyl)-2-p...)
Affinity DataIC50: 1.45E+5nMAssay Description:Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed