BDBM84805 1-azolyl-4-phenyl-2-butanone, 7

SMILES c1ccc(cc1)CCC(=O)Cn2cncn2

InChI Key InChIKey=WVMHBWUDAPTOQF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 84805   

TargetHeme oxygenase 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM84805(1-azolyl-4-phenyl-2-butanone, 7)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM84805(1-azolyl-4-phenyl-2-butanone, 7)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM84805(1-azolyl-4-phenyl-2-butanone, 7)
Affinity DataIC50: 2.50E+6nMpH: 7.4 T: 2°CAssay Description:Heme oxygenase activity in rat spleen and brain microsomal fractions was determined by the quantitation of CO formed from the degradation of methemal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed
TargetHeme oxygenase 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM84805(1-azolyl-4-phenyl-2-butanone, 7)
Affinity DataIC50: 1.80E+4nMpH: 7.4 T: 2°CAssay Description:Heme oxygenase activity in rat spleen and brain microsomal fractions was determined by the quantitation of CO formed from the degradation of methemal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed
TargetHeme oxygenase 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM84805(1-azolyl-4-phenyl-2-butanone, 7)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of HO-2 in Sprague-Dawley albino rat brain microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2020
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM84805(1-azolyl-4-phenyl-2-butanone, 7)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2020
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM84805(1-azolyl-4-phenyl-2-butanone, 7)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of HO-1 in Sprague-Dawley rat spleen microsomes using NADPH as substrate preincubated for 10 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHeme oxygenase 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM84805(1-azolyl-4-phenyl-2-butanone, 7)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of HO-2 in Sprague-Dawley rat brain microsomes using NADPH as substrate preincubated for 10 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed