BDBM84460 HIV-1 PR Inhibitor, compound 6

SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc1ccccc1)n1cc(COC(=O)N[C@@H]2[C@H](O)Cc3ccccc23)nn1

InChI Key InChIKey=MEWAZRJLRMEJDV-UHFFFAOYSA-N

Data  6 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 84460   

TargetProtease(Human immunodeficiency virus type 1)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataIC50: 6nMAssay Description:Inhibition of HIV1 protease after 24 hrs by LC/MS-SIM analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataIC50: 6nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL
LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant HIV1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  1.70nM IC50: 6nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL
LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to HIV1 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProtease(Human immunodeficiency virus type 1)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  2.70nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  10nM IC50: 19nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  22nM IC50: 39nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
The Scripps Research Institute

LigandPNGBDBM84460(HIV-1 PR Inhibitor, compound 6)
Affinity DataKi:  27nM IC50: 46nMAssay Description:The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed