BDBM8385 CHEMBL421207::N-[6-(furan-2-yl)-1H-indazol-3-yl]cyclopropanecarboxamide::indazole analogue 27

SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccco1)C1CC1

InChI Key InChIKey=IJMSMJUUYYSKBT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8385   

TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8385(N-[6-(furan-2-yl)-1H-indazol-3-yl]cyclopropanecarb...)
Affinity DataIC50: 50nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM8385(N-[6-(furan-2-yl)-1H-indazol-3-yl]cyclopropanecarb...)
Affinity DataIC50: 631nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8385(N-[6-(furan-2-yl)-1H-indazol-3-yl]cyclopropanecarb...)
Affinity DataIC50: 631nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2006
Entry Details Article
PubMed