BDBM83778 MLS000392284::N-[5-[4-(difluoromethylthio)benzyl]thiazol-2-yl]-4-methyl-benzamide::N-[5-[[4-(difluoromethylsulfanyl)phenyl]methyl]-1,3-thiazol-2-yl]-4-methylbenzamide::N-[5-[[4-(difluoromethylthio)phenyl]methyl]-2-thiazolyl]-4-methylbenzamide::N-[5-[[4-[bis(fluoranyl)methylsulfanyl]phenyl]methyl]-1,3-thiazol-2-yl]-4-methyl-benzamide::SMR000261226::cid_1527277

SMILES C[C@H]1CN(c2ncnc3c2c2ccc(S(=O)(=O)NC4(C#N)CC4)cc2n3-c2nnc(C(F)F)s2)CCN1C(=O)N(C)C

InChI Key InChIKey=MLXIDVMBHDPBJY-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 83778   

TargetPoly(ADP-ribose) glycohydrolase(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 83778BDBM83778((S)-4-(7-(N-(1-Cyanocyclopropyl)sulfamoyl)- 9-(5-(...)
Affinity DataIC50: 0.000100nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent