BDBM8349 6-aryl-pyrazolo[3,4-b]pyridine analogue 13::CHEMBL260417::N-[5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide::pyrazolo[3,4-b]pyridine analogue 4

SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1Br

InChI Key InChIKey=VNVKSDCWJDOWNE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 8349   

TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8349(pyrazolo[3,4-b]pyridine analogue 4 | N-[5-bromo-6-...)
Affinity DataIC50: 0.800nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8349(pyrazolo[3,4-b]pyridine analogue 4 | N-[5-bromo-6-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8349(pyrazolo[3,4-b]pyridine analogue 4 | N-[5-bromo-6-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM8349(pyrazolo[3,4-b]pyridine analogue 4 | N-[5-bromo-6-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8349(pyrazolo[3,4-b]pyridine analogue 4 | N-[5-bromo-6-...)
Affinity DataIC50: 5nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2006
Entry Details Article
PubMed