BDBM8330 N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl}butanamide::pyrazolopyridazine 5

SMILES CCCC(=O)Nc1n[nH]c2nnc(cc12)-c1ccccc1

InChI Key InChIKey=SKJDYCVWWBJYSF-UHFFFAOYSA-N

Data  1 IC50  1 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 8330   

TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8330(N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl}butan...)
Affinity DataIC50: 4nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8330(N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl}butan...)
Affinity DatapH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2006
Entry Details Article
PubMed