BDBM8277 3-(3-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]amino}-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 6hh

SMILES COc1cccc(c1)C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O

InChI Key InChIKey=JWKVIXXNQQUNBC-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8277   

TargetGlycogen synthase kinase-3 alpha(Human)
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8277(3-(3-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Affinity DataIC50: 203nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8277(3-(3-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Affinity DataIC50: 203nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8277(3-(3-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Affinity DataKi:  400nMAssay Description:Binding affinity human SLK by binding displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8277(3-(3-methoxyphenyl)-4-{[4-(methylsulfanyl)phenyl]a...)
Affinity DataKi:  3.50E+3nMAssay Description:Binding affinity human STK10 by binding displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed