BDBM8274 3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]amino}-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 6ee

SMILES CSc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)cc1

InChI Key InChIKey=XMKRZXOTGFXMPH-UHFFFAOYSA-N

Data  2 KI  2 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 8274   

TargetGlycogen synthase kinase-3 alpha(Human)
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataIC50: 161nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataIC50: 161nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of human MKNK1 by Kinomescan method relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataKd:  770nMAssay Description:Inhibition of wild-type human partial length SLK (S14 to A307 residues) expressed in bacterial expression system by Kinomescan method relative to con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataKd:  460nMAssay Description:Inhibition of wild-type human partial length CLK2 (D144 to R498 residues) expressed in bacterial expression system by Kinomescan method relative to c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataKd:  580nMAssay Description:Inhibition of wild-type human full length GSK3A (M1 to S483 residues) expressed in bacterial expression system by Kinomescan method relative to contr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of human PDPK1 by KINOMEscan assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataKi:  59nMAssay Description:Binding affinity human SLK by binding displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8274(3-(2-chlorophenyl)-4-{[4-(methylsulfanyl)phenyl]am...)
Affinity DataKi:  760nMAssay Description:Binding affinity human STK10 by binding displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed