BDBM8233 3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 6p

SMILES Oc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)c1

InChI Key InChIKey=RSOMSYHDLLNJGQ-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8233   

TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8233(3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Affinity DataKi:  56nMAssay Description:Binding affinity human SLK by binding displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8233(3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Affinity DataIC50: 374nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8233(3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Affinity DataIC50: 374nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8233(3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-2,5-...)
Affinity DataKi:  560nMAssay Description:Binding affinity human STK10 by binding displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed