BDBM82190 Salicylic acid derivative, compound 2

SMILES Cc1ccc(C)n1-c1ccc(O)c(c1)C(O)=O

InChI Key InChIKey=LBDOGIZEEBHJSE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 82190   

TargetEphrin type-A receptor 4 [1-949,A922V](Human)
Sanford-Burnham Medical Research Institute

LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Protein A-coasted wells (from Pierce Biotechnology) were used to immobilize Eph receptor Fc fusion proteins (from R&D systems)incubated at 1 ug/ml in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2011
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
Beth Israel Deaconess Medical Center

US Patent
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 7.00E+3nMAssay Description:Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetPyruvate kinase PKM(Human)
Beth Israel Deaconess Medical Center

US Patent
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His6/SUMO-tagged PKM1 expressed in Escherichia coli BL21 using PEP as substrate incubated for 30 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
Beth Israel Deaconess Medical Center

US Patent
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of recombinant human N-terminal His6/SUMO-tagged PKM2 expressed in Escherichia coli BL21 using PEP as substrate incubated for 30 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University

Curated by ChEMBL
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Escherichia coli GroEL/GroES-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University

Curated by ChEMBL
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 620nMAssay Description:Inhibition of Escherichia coli GroEL/GroES expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
Beth Israel Deaconess Medical Center

US Patent
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Beth Israel Deaconess Medical Center

US Patent
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed