BDBM82109 6,8,10-Traiazaspiro[4.5]deca-6,8-diene-7,9-diamine, Ie::CHEMBL1800937

SMILES NC1=NC2(CCCC2)N(OCCCOc2ccccc2)C(N)=N1

InChI Key InChIKey=YOMABOLLXZQEGZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 82109   

TargetDihydrofolate reductase(Bovine)
National University of Singapore

LigandPNGBDBM82109(CHEMBL1800937 | 6,8,10-Traiazaspiro[4.5]deca-6,8-d...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition activity using bovine dihydrofolate reductase (DHFR).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2011
Entry Details Article
PubMed
TargetDihydrofolate reductase(Bovine)
National University of Singapore

LigandPNGBDBM82109(CHEMBL1800937 | 6,8,10-Traiazaspiro[4.5]deca-6,8-d...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of bovine liver DHFR using dihydrofolic acid substrate by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM82109(CHEMBL1800937 | 6,8,10-Traiazaspiro[4.5]deca-6,8-d...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2019
Entry Details Article
PubMed