BDBM81975 4-hydroxyquinoline-2-carboxylic acid::CAS_492-27-3::CHEMBL299155::Kynurenate::NSC_5280455

SMILES c1ccc2c(c1)c(cc(n2)C(=O)O)O

InChI Key InChIKey=HCZHHEIFKROPDY-UHFFFAOYSA-N

Data  6 KI  2 IC50  7 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 81975   

TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataIC50: 4.02E+4nMAssay Description:Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataEC50:  3.92E+4nMAssay Description:Agonist activity at human GPR35 expressed in CHO cells assessed as increase in intracellular Ca2+ measured over 20 secs by Aequorin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataEC50:  1.52E+5nMAssay Description:Agonist activity at human GPR35 by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataEC50:  2.17E+5nMAssay Description:Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAryl hydrocarbon receptor(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataEC50:  300nMAssay Description:Activation of AHR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG protein-coupled receptor GPR35(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataEC50:  6.60E+4nMAssay Description:Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataEC50:  1.52E+5nMAssay Description:Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataEC50: >5.00E+5nMAssay Description:Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataKi:  5.40E+3nMAssay Description:Ability to displace strychnine-insensitive [3H]glycine binding to rat cortical membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataKi:  5.40E+3nMAssay Description:Tested for the ability to displace [3H]glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetVesicular glutamate transporter 3(Rat)
The University of Montana

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataKi:  1.30E+6nMAssay Description:Compound was evaluated for the inhibition of Vesicular glutamate transporter (VGLUT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM81975(4-hydroxyquinoline-2-carboxylic acid | NSC_5280455...)
Affinity DataKi:  1.37E+5nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed