BDBM81962 S-L-365,260

SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1

InChI Key InChIKey=KDFQABSFVYLGPM-UHFFFAOYSA-N

Data  16 KI  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 43 hits for monomerid = 81962   

TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 2nMAssay Description:Antagonistic activity against cholecystokinin type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against gastrin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 280nMAssay Description:Concentration required for 50% inhibition of Cholecystokinin type A receptor in rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 2nMAssay Description:Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 280nMAssay Description:Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 2nMAssay Description:Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
University of Paris

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 39nMAssay Description:Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 736nMAssay Description:Binding activity against Cholecystokinin type A receptor from rat pancreas using [125]BH CCK-8s as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 8.5nMAssay Description:Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 5.10nMAssay Description:Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 230nMAssay Description:Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to rat pancreas cholecystokinin type A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 5.10nMAssay Description:Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 230nMAssay Description:Evaluated for inhibition of CCK-A receptor by displacing [125I]bolton hunter CCK-8 radioligand in the rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 280nMAssay Description:Inhibition of binding of [125I]- CCK-33 to rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 1.10nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 2nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 230nMAssay Description:Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 740nMAssay Description:Inhibition of binding of [125I]CCK-8 to cholecystokinin type A receptor in rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 280nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Guinea pig)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 2nMAssay Description:Inhibition of binding of [125I]- CCK-33 to guinea pig cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 29nMAssay Description:Inhibitory concentration against Cholecystokinin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 158nMAssay Description:Displacement of CCK-8 from CHO cell membranes expressing human Cholecystokinin type A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50: 6.30nMAssay Description:Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  0.148nMAssay Description:Inhibition by displacing [3H]CCK-8S against Cholecystokinin type A receptor of rat pancreatic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  1.60nMAssay Description:Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  1.80nMAssay Description:The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  2nMAssay Description:Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  3nMAssay Description:Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM81962(S-L-365,260)
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  3.70nMAssay Description:Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  4nMAssay Description:Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
University of Paris

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  12nMAssay Description:Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
University of Paris

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  15nMAssay Description:Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  151nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
University of Paris

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  269nMAssay Description:Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Guinea pig)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  316nMAssay Description:Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Guinea pig)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  468nMAssay Description:Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type A receptor binding sites on guinea pig-pancreat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed