BDBM81730 HSP90 Inhibitor, 4

SMILES Cc1cc(nc(N)n1)-c1ccc(Cl)cc1Cl

InChI Key InChIKey=SVSRFLUHRBVOHK-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 81730   

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81730(HSP90 Inhibitor, 4)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of HSP90 in human H1299 cells assessed as degradation of Akt protein after 24 hrs by luminex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

LigandPNGBDBM81730(HSP90 Inhibitor, 4)
Affinity DataKi:  170nM ΔG°:  -9.23kcal/molepH: 7.5 T: 2°CAssay Description:HSP90 inhibitors identified using Fluorescence resonance energy transfer assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2011
Entry Details Article
PubMed