BDBM81356 PF-3845, 10::US20240308985, Comparator TableD2.2::US20250170100, Compound Comparator 2

SMILES c1cc(cc(c1)Oc2ccc(cn2)C(F)(F)F)CC3CCN(CC3)C(=O)Nc4cccnc4

InChI Key InChIKey=NBOJHRYUGLRASX-UHFFFAOYSA-N

Data  1 KI  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 81356   

TargetFatty-acid amide hydrolase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM81356(PF-3845, 10 | US20240308985, Comparator TableD2.2 ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAAH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM81356(PF-3845, 10 | US20240308985, Comparator TableD2.2 ...)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM81356(PF-3845, 10 | US20240308985, Comparator TableD2.2 ...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human transmembrane domain deficient FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM81356(PF-3845, 10 | US20240308985, Comparator TableD2.2 ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human FAAH using N-(6-methoxypyridin-3-yl)octanamide as a substrate assessed as reduction in 6-methoxypyridin-3-amine formation by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM81356(PF-3845, 10 | US20240308985, Comparator TableD2.2 ...)
Affinity DataIC50: 14nMAssay Description:MAGL inhibitor compounds were also counter-screened for FAAH inhibition potency using the following assay. Assessment of FAAH inhibition was performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM81356(PF-3845, 10 | US20240308985, Comparator TableD2.2 ...)
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2025
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM81356(PF-3845, 10 | US20240308985, Comparator TableD2.2 ...)
Affinity DataKi:  230nMAssay Description:Enzyme-coupled assay using oleamide as substrate where stoichiometic quantites of NAD are formed upon the generation of ammonia from oleamide by FAAH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed