BDBM808650 7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-1-methyl-2- piperidyl]methyl]isoquinoline-3,5- diamine::US12637428, Example E78

SMILES Cc1cccc(F)c1-c1cc(NC[C@@H]2CCCCN2C)c2cc(N)ncc2c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808650   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808650BDBM808650(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-1-methyl-2...)
Affinity DataKi:  0.0930nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808650BDBM808650(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-1-methyl-2...)
Affinity DataKi:  0.433nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808650BDBM808650(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-1-methyl-2...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808650BDBM808650(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-1-methyl-2...)
Affinity DataKi:  6.85nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808650BDBM808650(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-1-methyl-2...)
Affinity DataKi:  43.3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808650BDBM808650(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-1-methyl-2...)
Affinity DataKi:  119nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent