BDBM79601 4-[4-[[4-chloranyl-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide;4-methylbenzenesulfonic acid::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid::4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxomethyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide;4-methylbenzenesulfonic acid::MLS002415564::SMR001339079::cid_406563

SMILES CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl

InChI Key InChIKey=MLDQJTXFUGDVEO-UHFFFAOYSA-N

Data  1 KI  15 IC50

PDB links: 8 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 79601   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of wild type human recombinant RET expressed in baculovirus by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataKi:  6nMAssay Description:Inhibition of c-Raf (unknown origin) assessed as apparent inhibition constant incubated for 25 mins in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly (Glu,Tyr) 4:1 as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor beta(Human)
Taipei Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 40nMAssay Description:Inhibition of PDGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human VEGFR2 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 58nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 45 mins in presence of ATP by microplate reade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 90nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant VEGFR2 (805 to 1356 residues) in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Hubei University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human EGFR using TMB as substrate preincubated with compound for 1 hr followed by substrate addition and measured after 30 mins by ELIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of Raf in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 6.16E+3nMAssay Description:Inhibition of Raf in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 7.46E+3nMAssay Description:Inhibition of RAF in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 8.97E+3nMAssay Description:Inhibition of Raf in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 9.64E+3nMAssay Description:Inhibition of Raf in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 79601BDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Raf in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed