BDBM789789 2-(cyanomethyl)-7-((2S,5R)-4-(1-(3,3-dimethyl-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-4-methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitrile::US20250353858, Compound A12a

SMILES C[C@@H]1CN(c2c(C#N)c(=O)n(C)c3cc(CC#N)nn23)[C@@H](C)CN1[C@@H](C)c1ccc2c(c1)OC(C)(C)CO2

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 789789   

TargetDiacylglycerol kinase zeta(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 789789BDBM789789(2-(cyanomethyl)-7-((2S,5R)-4-(1-(3,3-dimethyl-2,3-...)
Affinity DataIC50: 11nMAssay Description:Enzymatic reactions of DGKζ, DGKα and DGKδ were performed using ADP-Glo assay with lipid micelle substrate. Full length DGKζ in-house protein M1-V929...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetDiacylglycerol kinase alpha(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 789789BDBM789789(2-(cyanomethyl)-7-((2S,5R)-4-(1-(3,3-dimethyl-2,3-...)
Affinity DataIC50: 1.25E+4nMAssay Description:Enzymatic reactions of DGKζ, DGKα and DGKδ were performed using ADP-Glo assay with lipid micelle substrate. Full length DGKζ in-house protein M1-V929...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent