BDBM7875 2-bromo-1-phenylethan-1-one::CHEMBL102953::Halomethyl Phenyl Ketone deriv. 23

SMILES c1ccc(cc1)C(=O)CBr

InChI Key InChIKey=LIGACIXOYTUXAW-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7875   

TargetGlycogen synthase kinase-3 beta [7-25](Rabbit)
Instituto De Quimica Medica (Csic)

LigandPNGBDBM7875(2-bromo-1-phenylethan-1-one | CHEMBL102953 | Halom...)
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Central University

Curated by ChEMBL
LigandPNGBDBM7875(2-bromo-1-phenylethan-1-one | CHEMBL102953 | Halom...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of glycogen synthase kinase-3 beta (unknown origin) using GS-1 as substrate after 20 mins by scintillation counting analysis in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Central University

Curated by ChEMBL
LigandPNGBDBM7875(2-bromo-1-phenylethan-1-one | CHEMBL102953 | Halom...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of GSK3-beta using GS1 as substrate and [gamma-32P]ATP after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM7875(2-bromo-1-phenylethan-1-one | CHEMBL102953 | Halom...)
Affinity DataKi:  8.10E+4nMAssay Description:Dissociation constant towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed