BDBM785433 4-chloro-1-(5- (difluoromethyl)-1,3,4- thiadiazol-2-yl)-N-(2,3- dimethyloxetan-3-yl)-1H- indazole-6-sulfonamide::US20250346564, Example 71

SMILES CC1OCC1(C)NS(=O)(=O)c1cc(Cl)c2cnn(-c3nnc(C(F)F)s3)c2c1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 785433   

TargetPoly(ADP-ribose) glycohydrolase(Human)
ARase Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785433BDBM785433(4-chloro-1-(5- (difluoromethyl)-1,3,4- thiadiazol-...)
Affinity DataIC50: 275nMAssay Description:The ability of the compounds of the Examples to inhibit PARG activity in 4. (trifluoromethyl)umbelliferone (TFMU) assay was determined as described b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent