BDBM77522 1-(3-chlorobenzyl)-2-keto-4-phenyl-nicotinonitrile::1-(3-chlorobenzyl)-2-oxo-4-phenyl-1,2-dihydro-3-pyridinecarbonitrile::1-[(3-chlorophenyl)methyl]-2-oxidanylidene-4-phenyl-pyridine-3-carbonitrile::1-[(3-chlorophenyl)methyl]-2-oxo-4-phenyl-3-pyridinecarbonitrile::1-[(3-chlorophenyl)methyl]-2-oxo-4-phenylpyridine-3-carbonitrile::MLS000326966::SMR000179592::cid_1487451

SMILES O=C(CCN1CCOCC1)Nc1ccc2c(=O)n(CC3(O)CCN(C(=O)C(CCCNC(=O)c4ccc5c(Cl)c6c(nc5c4)CCCC6)Cc4ccc(F)c(C(F)(F)F)c4)CC3)cnc2c1

InChI Key InChIKey=MZDZRITYUUKHOF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 77522   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 77522BDBM77522(US12503453, Compound Table3.18 | US12503453, Compo...)
Affinity DataIC50: 60nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2026
Entry Details
US Patent