BDBM768 4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one::CHEMBL16694::phenprocoumon

SMILES CCC(c1ccccc1)c1c(O)c2ccccc2oc1=O

InChI Key InChIKey=DQDAYGNAKTZFIW-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 768   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Peking University

Curated by ChEMBL
LigandPNGBDBM768(4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one | CH...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against human immunodeficiency virus 1 protease in MT-4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM768(4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one | CH...)
Affinity DataIC50: 5.28E+5nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rat)
Claude Bernard University Lyon 1

Curated by ChEMBL
LigandPNGBDBM768(4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one | CH...)
Affinity DataKi:  200nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2019
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Peking University

Curated by ChEMBL
LigandPNGBDBM768(4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one | CH...)
Affinity DataKi:  800nMAssay Description:Binding affinity towards HIV protease was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM768(4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one | CH...)
Affinity DataKi:  1.00E+3nMAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2017
Entry Details Article
PubMed