BDBM755066 Synthesis of (7R,E)-31,7-Dimethyl-18-(methylamino)-31H-5-oxa-2,8-diaza-1(6,3),3(4,6)-diimidazo[1,2-b]pyridazinacyclononaphan-9-one ::US20250213571, Compound 1

SMILES CNc1cc2nn3c(cnc13)C(=O)N[C@H](C)COCc1cc(c3c(c1)nnn3C)N2

InChI Key InChIKey=WTBVMGJOTHPBRF-UHFFFAOYSA-N

Data  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 755066   

LigandPNGBDBM755066(Synthesis of (7R,E)-31,7-Dimethyl-18-(methylamino)...)
Ligand Info
In Depth
Date in BDB:
10/22/2025
Entry Details
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LigandPNGBDBM755066(Synthesis of (7R,E)-31,7-Dimethyl-18-(methylamino)...)
Affinity DataKd:  5.50E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/22/2025
Entry Details
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TargetTyrosine-protein kinase JAK3 [811-1124](Human)
Alumis

US Patent
LigandPNGBDBM755066(Synthesis of (7R,E)-31,7-Dimethyl-18-(methylamino)...)
Affinity DataKd: <3.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/22/2025
Entry Details
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TargetTyrosine-protein kinase JAK2 [536-812](Human)
Alumis

US Patent
LigandPNGBDBM755066(Synthesis of (7R,E)-31,7-Dimethyl-18-(methylamino)...)
Affinity DataKd:  5.50E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/22/2025
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Alumis

US Patent
LigandPNGBDBM755066(Synthesis of (7R,E)-31,7-Dimethyl-18-(methylamino)...)
Affinity DataKd: <3.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/22/2025
Entry Details
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TargetTyrosine-protein kinase JAK1 [583-855](Human)
Alumis

US Patent
LigandPNGBDBM755066(Synthesis of (7R,E)-31,7-Dimethyl-18-(methylamino)...)
Affinity DataKd:  505nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/22/2025
Entry Details
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TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Alumis

US Patent
LigandPNGBDBM755066(Synthesis of (7R,E)-31,7-Dimethyl-18-(methylamino)...)
Affinity DataKd: <3.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/22/2025
Entry Details
Go to US Patent