BDBM753528 6-(2-fluoroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.3.1]heptan-3-yl)pyridin-3-yl)-1H-pyrazolo[3',4':3,4]pyrazolo[1,5-a]pyridine ::US12338253, Compound 31

SMILES COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(OCCF)cn5nc6[nH]ncc6c45)cn2)C3)cn1

InChI Key InChIKey=AWMOPIBVZHOHND-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 753528   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM753528(6-(2-fluoroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/17/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM753528(6-(2-fluoroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/17/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM753528(6-(2-fluoroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Ligand Info
In Depth
Date in BDB:
10/17/2025
Entry Details
Go to US Patent