BDBM7498 (2Z)-2-benzylidene-4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-1-benzofuran-3(2H)-one::(2Z)-4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-2-(phenylmethylidene)-2,3-dihydro-1-benzofuran-3-one::Benzofuranone deriv. 4::CHEMBL51709

SMILES CN1CCC(CC1)c1c2O\C(=C/c3ccccc3)C(=O)c2c(O)cc1O

InChI Key InChIKey=HGFLDVQTDYSNRS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 7498   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Novartis Pharmaceuticals

LigandPNGBDBM7498(CHEMBL51709 | (2Z)-2-benzylidene-4,6-dihydroxy-7-(...)
Affinity DataIC50: 110nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Novartis Pharmaceuticals

LigandPNGBDBM7498(CHEMBL51709 | (2Z)-2-benzylidene-4,6-dihydroxy-7-(...)
Affinity DataIC50: 1.28E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM7498(CHEMBL51709 | (2Z)-2-benzylidene-4,6-dihydroxy-7-(...)
Affinity DataIC50: 4.41E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 7.5 uM ATP/ [gamma-33P] ATP. 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM7498(CHEMBL51709 | (2Z)-2-benzylidene-4,6-dihydroxy-7-(...)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM7498(CHEMBL51709 | (2Z)-2-benzylidene-4,6-dihydroxy-7-(...)
Affinity DataIC50: 1.28E+3nMAssay Description:Evaluated for inhibition of human cyclin dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM7498(CHEMBL51709 | (2Z)-2-benzylidene-4,6-dihydroxy-7-(...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed