BDBM74978 1,3-dihydrobenzo[e]benzimidazole-2-thione::CHEMBL1456134::MLS000707941::SMR000289008::cid_1104317

SMILES S=c1[nH]c2ccc3ccccc3c2[nH]1

InChI Key InChIKey=BXYPGICASMVMLQ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 74978   

TargetImportin subunit alpha-1(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM74978(CHEMBL1456134 | cid_1104317 | SMR000289008 | MLS00...)
Affinity DataEC50: >5.00E+5nMAssay Description:Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM74978(CHEMBL1456134 | cid_1104317 | SMR000289008 | MLS00...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM74978(CHEMBL1456134 | cid_1104317 | SMR000289008 | MLS00...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed