BDBM747218 (S)-(7,8-dichloro-1-methyl-3,4-dihydropyrazino[1,2-b]indazol-2(1H)-yl)(5- methoxypyrimidin-2-yl)methanone::US20250179079, Compound 52B

SMILES COc1cnc(C(=O)N2CCn3nc4c(Cl)c(Cl)ccc4c3[C@@H]2C)nc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 747218   

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandPNGBDBM747218((S)-(7,8-dichloro-1-methyl-3,4-dihydropyrazino[1,2...)
Affinity DataIC50: 71.5nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent