BDBM746046 (R or S)-3-(4-(5-chloro-1-(1-cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl)piperazin-1-yl)-3-methyltetrahydrothiophene 1,1-dioxide and (S or R)-3-(4-(5-chloro-1-(1-cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl)piperazin-1-yl)-3-methyltetrahydrothiophene 1,1-dioxide::US12319671, Example 4.14

SMILES C[C@@]1(N2CCN(c3cc4c(cnn4-c4cnn(C5CC5)c4)cc3Cl)CC2)CCS(=O)(=O)C1

InChI Key InChIKey=FDOWKWMHEKHHAV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 746046   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746046((R or S)-3-(4-(5-chloro-1-(1-cyclopropyl-1H-pyrazo...)
Affinity DataIC50: 625nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent