BDBM746036 (S or R)-5-chloro-1-(1-cyclopropyl-1H-pyrazol-4-yl)-6-(4-(3-methyltetrahydrofuran-3-yl)piperazin-1-yl)-1H-indazole and (R or S)-5-chloro-1-(1-cyclopropyl-TH-pyrazol-4-yl)-6-(4-(3-methyltetrahydrofuran-3-yl)piperazin-1-yl)-1H-indazole::US12319671, Example 4.4

SMILES C[C@]1(N2CCN(c3cc4c(cnn4-c4cnn(C5CC5)c4)cc3Cl)CC2)CCOC1

InChI Key InChIKey=SZQZMAGNJVDDDR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 746036   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746036((S or R)-5-chloro-1-(1-cyclopropyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 672nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746036((S or R)-5-chloro-1-(1-cyclopropyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 625nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent