BDBM745664 US12319655, Example 144

SMILES Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)CC#N)c2)n1

InChI Key InChIKey=IPQGMDOWNGUQGX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 745664   

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745664(US12319655, Example 144)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [416-766](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745664(US12319655, Example 144)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745664(US12319655, Example 144)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745664(US12319655, Example 144)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent